Investigating Inflammatory Arthritis
A number of different strategies for dealing with arthritis are presently in the research queue. Medical News Today reports on hints of yet another potential methodology: "Mice lacking [the protein] T-bet had markedly reduced joint inflammation and T-bet-deficient mice without T or B cells were essentially resistant to disease. They also found that transfer of normal dendritic cells that make T-bet, but not T-bet-deficient dendritic cells, into mice unable to make T cells, B cells or T-bet, was able to cause inflammatory arthritis. The study shows that the ability of dendritic cells to secrete proinflammatory molecules and to prime T cells to initiate an immune response is compromised in the absence of T-bet. T-bet could provide an attractive new target for therapy in inflammatory arthritis."
Link: http://www.medicalnewstoday.com/medicalnews.php?newsid=36120