Sinclair, Guarente on Longevity Genes
The latest Scientific American takes a good look at research into the genetics and biochemistry of calorie restriction: "Because people have sought to slow aging for tens of thousands of years without success, some may find it hard to accept that human aging might be controlled by tweaking a handful of genes. Yet we know it is possible to forestall aging in mammals with a simple dietary change: calorie restriction works. And we have shown that Sirtuin genes control many of the same molecular pathways as calorie restriction. Without actually knowing the precise, and potentially myriad, causes of aging, we have already demonstrated in a variety of life-forms that it can be delayed by manipulating a few regulators and letting them take care of the organisms' health."