Ashkenazi Jew Centenarian Studies

Science has an update for those following the study of longevity genes in the Ashkenazi Jew population: "In 2003, [scientists] discovered that people with a certain polymorphism of the cholesterol-influencing gene CETP lived longer than those without it ... Now the researchers have identified another part of the longevity code. ... 25% of the centenarians carried a particular variation of the gene APOC3, which helps determine cholesterol levels. ... A drug that mimics the function of the CETP gene is already in development [and] the same could happen with APCO3. Eventually multiple gene functions could be simulated by a single pill." This is a similar approach to that followed by calorie restriction researchers - start with what works, find the genes, find the mechanisms, influence both to slow the rate of damage. SENS supporters would claim there are more effective paths forward to the goal of extended healthy life spans, however.

Link: http://sciencenow.sciencemag.org/cgi/content/full/2006/404/1

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