Gene Vaccination Versus Amyloid-Beta

Science Daily reports on progress towards turning our immune systems against amyloid beta, the protein that forms plaques in Alzheimer's disease: "By pressure-injecting the gene responsible for producing the specific protein -- called amyloid-beta 42 -- the researchers caused the mice to make antibodies and greatly reduce the protein's build-up in the brain. ... While the mice were young, the scientists coated microscopically small gold particles with human amyloid-beta 42 genes attached to other genes that program cells to make the protein. The particles were then injected with a gene gun into the skin cells of the mice's ears using a blast of helium. After receiving 11 injections over several months, the mice showed a high level of antibodies to amyloid-beta 42, and a 60 percent to 77.5 percent reduction of plaques in their brains."

Link: http://www.sciencedaily.com/releases/2006/04/060401111932.htm

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