Aging, Immunodeficiency, Inflammation

Via the open-access journal Immunity & Aging, a look at how the aging immune system harms us by doing both too little and too much (a full PDF is available): "Aging is associated with a paradox of immunodeficiency and inflammation (an evidence of hyperactive immune system). Apoptosis is associated with cellular depletion and suppression of inflammatory response. In this brief review, we will present evidence for the role of increased apoptosis in immunodeficiency and paradoxical increased inflammation associated with human aging. In particular, a role of apoptotic antibodies in failure to generate anti-inflammatory responses in dendritic cells will be discussed."



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