Cause of Angiogenesis in AMD

EurekAlert! notes another step towards preventing age-related macular degeneration (AMD): "Uncontrolled blood vessel growth (angiogenesis) is a major contributor to the development of age-related macular degeneration (AMD) ... [researchers] found that the molecule, Carboxyethylpyrroles (CEPs), attaches to proteins found in the eye, triggering the uncontrolled growth of blood cells. ... The researchers did in vivo animal studies with membranes from chicken eggs and rat eyes and found that CEPs attached to proteins induce angiogenesis. They also found that the protein part of CEP-protein adducts is not important for producing the growth of the blood vessels. Rather, the actual CEP is the cause of angiogenesis. In an attempt to block CEP from triggering the angiogenesis process [we] are now trying to find the receptors - the keyholes - in the retina cells that are activated by CEPs. We are also designing drugs that can mop up the CEPs or prevent their formation."



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