Ouroboros follows up on some of the more interesting recent research into the links between autophagy and age-related degeneration: "An old proverb has it that what is not growing is dying. Recent findings regarding autophagy - a process by which cells turn over old proteins and clear cellular detritus - lead me to believe that what is not self-degrading is also dying. A while back, we discussed a review that summarized the slowing of autophagy with increasing age. The efficiency of turnover decreases as an animal grows older, potentially creating a garbage catastrophe as increasing levels of damaged macromolecules further gum up the works. The upcoming issue of Molecular Aspects of Medicine has three reviews that treat various aspects of autophagy and aging in greater depth."