Rheumatoid Arthritis and p38

The New Scientist reports on a recent PLoS Medicine paper: "People with rheumatoid arthritis tend to die about five to 10 years earlier than others, so this is not just feeling stiff in the morning ... Nerves in bodily extremities, such as hands and feet, can produce compounds that increase inflammation. The new results suggest that p38 [an enzyme involved in joint inflammation] is an early part of the pathway that sends signals from the central nervous system to these distant nerves ... Clinical trials are currently underway to test if blocking p38 throughout the body can stop the progression of arthritis in humans." Chronic inflammation is no joke when it comes to consequences for your health and life span; it seems to be a potent source of age-related damage.

Link: http://www.newscientist.com/article/dn9994-spine-injection-cuts-arthritis-inflammation.html


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