Elixir and Sirtris

The Boston Herald characterizes the present efforts of companies attempting to manipulate the biochemistry behind calorie restriction: "this is hardly a Ponce de Leon-esque expedition. The Food and Drug Administration does not consider aging a condition that requires treatment." Which means that no venture capitalists will fund real longevity research, because treatments will not be approved, ergo no profit and no direct progress - what a waste! "So researchers are developing drugs to treat or prevent aging-related diseases like diabetes or obesity. The current explosion of anti-aging research dates to the 1930s when scientists discovered that dramatically reducing an animal's caloric intake will pile on extra years. ... Sirtris researchers have developed small molecules aimed at triggering the health-promoting effects from caloric restriction found in sirtuins, a class of enzymes. Elixir is also researching sirtuins, but it's seeking ways to treat diabetes and obesity by targeting ghrelin, a protein released in the stomach that regulates hunger and metabolic functions."

Link: http://news.bostonherald.com/localRegional/view.bg?articleid=165714

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