More On Inflammaging

"Inflammaging" is a packaging of the present understanding of the way in which chronic inflammation and a failing immune system interact to contribute to degenerative aging. From this paper: "A large part of the aging phenotype, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks, which results in the low grade chronic pro-inflammatory status we proposed to call inflammaging. Within this perspective, healthy aging and longevity are likely the result not only of a lower propensity to mount inflammatory responses but also of efficient anti-inflammatory networks, which in normal aging fail to fully neutralize the inflammatory processes consequent to the lifelong antigenic burden and exposure to damaging agents. Such a global imbalance can be a major driving force for frailty and common age-related pathologies."

Link: http://dx.doi.org/10.1016/j.mad.2006.11.016

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