From the BBC, news of a study of high dose resveratrol given to obese mice: "After six months, resveratrol essentially prevented most of the negative effects of the high calorie diet in mice. ... The 'healthspan' benefits we saw in the obese mice treated with resveratrol are positive clinical indicators and may mean we can stave of in humans age-related diseases such as type 2 diabetes, heart disease and cancer, but only time and more research will tell." Resveratrol appears to trigger the same or similar biochemical mechanisms as calorie restriction; studies have also been run in fish. Personally, I want to see the results of a high dose study in normally fed or calorie restricted mice. What does that do? Preventing the detrimental effects of obesity is a big deal in the wealthy, fattened regions of the world, but it isn't healthy life extension.