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More On IGF-1 and Calorie Restriction

Calorie restriction (or rather protein restriction in this case - there is a difference) is linked with reduced levels of insulin-like growth factor-1 (IGF-1): "people on a low-protein, low-calorie diet had considerably lower levels of a particular plasma growth factor called IGF-1 than equally lean endurance runners ... That suggests to us that a diet lower in protein may have a greater protective effect against cancer than endurance exercise, independently of body fat mass. ... Past research has linked pre-menopausal breast cancer, prostate cancer and certain types of colon cancer to high levels of IGF-1, a powerful growth factor that promotes cell proliferation. Data from animal studies also suggest that lower IGF-1 levels are associated with maximal lifespan." Some commenters feel that the study didn't control enough of the other variables to make any strong suggestion, but the evidence is piling up.

Link: http://mednews.wustl.edu/news/page/normal/8388.html

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