Alzheimer's Vaccine Effective For Mice

From MSNBC, news that another potential Alzheimer's vaccine has passed the animal model test: "Japanese scientists have developed an oral vaccine for Alzheimer's disease that has proven effective and safe in mice ... The team is preparing to move to small-scale clinical trials in humans, possibly this year ... We hope the Phase I trials go well. Animals are able to recover their functions after developing symptoms, but humans are less able to do so. It may be that this only works in the early stages of the disease, when symptoms are light ... The vaccine is made by inserting amyloid-producing genes into a non-harmful virus. When taken orally, the virus stimulates the immune system to attack and break down the amyloid proteins in the brain ... The treatment was tested on 28 mice genetically modified to develop Alzheimer's disease. Half the animals were given a dose of the vaccine at the age of 10 months, while the control group were not treated. Three months later, tests showed mental function in the treated mice had returned to levels close to those before they developed Alzheimer's symptoms."

Link: http://www.msnbc.msn.com/id/17853445/

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