2theadvocate.com notes that the CALERIE study of calorie restriction in humans is once more looking for volunteers: "Scientists at the Pennington Biomedical Research Center are looking for volunteers to figure out how cutting calories daily by 25 percent helps people live longer and healthier lives. A team led by Eric Ravussin recently found that cutting calories in an otherwise nutritious diet causes a slowdown of the aging process. Participants were also healthier, but Ravussin doesn't yet know what caused it. ... All participants in the calorie restriction study ate less and exercised more, so they also lost weight. We're not sure if their bodies reacted biologically to the decrease in calories or to the weight loss. That's what we're trying to learn now, but we need help. ... the clinical study requires participants to enroll in a 26-month trial. Pennington is looking for lean or slightly overweight volunteers who will eat either a restricted calorie diet or a normal diet. Both groups will also visit the center for a sophisticated series of tests to determine health status, metabolic rate, DNA damage and other measures." Find out how to enroll at the CALERIE website.