Calorie Restriction Research Roundup

As Chris Patil notes, "The calorie restriction (CR) literature is exploding: dozens of papers are published each month, many of which are noteworthy in some way. ... Calorie restriction in adult men and women causes beneficial metabolic, hormonal, and functional changes, but the precise amount of calorie intake or body fat mass associated with optimal health and maximum longevity in humans is not known ... Fertility was not altered by CR in any of the examined groups. ... This preliminary study encourages speculation that mild regimens of CR can produce health and longevity benefits without the 'costs' of impaired reproductive potential. ... These observations combined with the recent suggestion of active alterations in aging processes by antiaging genes do suggest the potential for significant beneficial effects of CR in humans consistent with the effects that are emerging in the nonhuman primate studies. However, some theoretical analyses alternatively suggest that there may be only a limited potential of CR to extend lifespan and reduce morbidity in humans."


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