Science at the Edmonton Aging Symposium

One of the scientists attending the Edmonton Aging Symposium talks about the event at Ouroboros: it "was an interesting mix: scientists from all over the interdisciplinary field of aging research, and educated laymen who have a keen interest in our work. ... Irina Conboy (my boss) presented our lab's currently in-press data on how an aged tissue environment negatively affects the ability of muscle stem cells to differentiate. The proximity of [embryonic stem cells], however, can locally rescue the affects of a 'polluted' niche. We are currently investigating the soluble factors that regulate the ability of cells and tissues to renew and regenerate. ... Ellen Heber-Katz gave an update on the MRL (Murphy Roths Large) mouse story. She has discovered that this regenerating mouse breaks down the basement membrane in the vicinity of an injury (apparently similarly to other, more 'traditionally' regenerating creatures such as salamanders). Matrix metalloproteinases secreted by inflammatory cells recruited to the wound site are apparently essential to this aspect of the healing process."


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