The Latest Mprize Competitor Steps Forward

The Methuselah Foundation announces the latest competitor for the Mprize: "The focus of Mr. Cash's research and development at Terra Biological LLC is on small molecules that simulate the genomic effects of caloric restriction ("caloric restriction mimics" or "CR mimetics"). CR mimetics have been shown to increase the lifespan of laboratory test animals, namely C. Elegans worms, D. Melanogater flies and, in a small pilot test, M. Musculus mice by up to 36%. ... The NIA/NIH is currently evaluating the inclusion of one of Terra Biological's CR mimetics in its ITP test program in mice to measure its biological effects on life and health span. These larger scale mouse tests will constitute the entry into the Mprize competition. ... My hopes in entering the Mprize competition are to demonstrate and confirm, on a larger scale in mice, the effectiveness of specific small molecule, biochemical control of aging. This biochemical control, which has already been shown to simulate calorie restriction - CR, a scientifically tested and accepted method of increasing life and health span - will be tested beginning with middle aged mice, about 16 months old."


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