This paper is a reminder of the power of modern biotechnology to pull information from our biochemistry. Want to learn more about aging? Why not start by building a database of changes in levels, usage and alterations in every protein in the body with age? "The scope of the current paper is to review existing and potential applications of proteomic analysis to aging research. The focus will lie on the unique opportunities of high-throughput studies for uncovering specific alterations in protein expression, protein complexes or protein modifications caused by biological aging. The result of such studies will outline aging phenotypes and potentially indicate pathways involved in the pathogenesis of age-associated disfunctions. Specific attention is paid to the illustrations of successful applications of proteomic technologies and potential applications of new proteomic concepts to biogerontological studies." The rate at which scientists can build such a database is presently far in advance of the rate at which they can extract meaning from it, but that's no reason not to get started.