From the Daily Reveille: "Pennington Biomedical Research Center conducts what Assistant Communications Director Alan Pesch called an 'exciting' two-year study on the effects of calorie restriction. The new study, CALERIE II, marks the second phase of a $12.4 million, seven-year study launched in 2002. ... Pennington researchers and others have already successfully linked caloric restriction to longevity in small animals and organisms. ... We know it's been working for flies, worms, yeast and then mammals like rats and mice. All the data are consistent, and the question is: Do we have any evidence that it can work in humans? ... Pennington will use a variety of techniques to analyze test subjects' metabolism, which may affect longevity. Researchers will also examine genes they believe may control bodily responses to caloric restriction. Though the study examines the effects of caloric restriction, Pennington plans to test whether subjects can realize a longer life through increasing activity levels. ... There is something we don't understand totally that keeps your cells in the body younger ... Pennington will accept 100 qualified men and women for the upcoming two-year study. Enrollment begins in late summer."