I am reminded by Bruno Giussani that the release date for Aubrey de Grey and Michael Rae's "Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime" is another month closer - September is right around the corner. Giussani provides a short blog interview with de Grey:
How has your research progressed since your TEDGLOBAL05 and TED06 speeches?
The Methuselah Foundation has gone from strength to strength. The biggest development, among other donations, was the pledge of $3.5m from TEDster and PayPal co-founder Peter Thiel, which resulted from a dialogue that began at TED. Most of his pledge ($3m of it) is a 1:2 challenge, so out current goal is to obtain $6m from elsewhere to match that pledge in full.
OK, that's about the funding. But how's the research going?
It's been going really well too. We are currently sponsoring research by three teams (in Phoenix, Houston and Cambridge UK) on two of the most important SENS strands - LysoSENS, the identification and exploitation of microbial enzymes to break down molecules that we cannot naturally degrade, and MitoSENS, the incorporation of modified copies of the mitochondrial DNA into the chromosomal DNA so that mitochondrial mutations will have no effect. Both these projects are going really well, results coming out of the LysoSENS project have already been presented at two meetings and a paper has been submitted for publication in a prominent journal.
What should readers expect to learn from the book?
They will learn all about the detailed science of SENS. The book is written (largely by my splendid research assistant Michael Rae) very much for a non-scientist audience, but without dumbing down the science at all.
Having helped out with the editing a little here and there, I can attest to it being a very fine book indeed.
Aimed squarely at folk who want to know more about the science of repairing the molecular damage that causes aging, but find navigating the wild waterways of scientific publications too intimidating or time-consuming, this is a step by step, detailed explanation of how we could achieve radical life extension within our lifetimes, as best we understand from our present knowledge of our biochemistry.
If you're used to the "eat this, take supplements and exercise" longevity bookshelf, Ending Aging is a big step up - very much more "research this science to develop this specific therapy based upon that sound basis established over the past two decades." You'll be seeing more of that in the years ahead, and this exactly where your attention should be focused if you care about your own longevity.