Ouroboros looks at the role of sirtuins in relation to age-related neurodegenerative conditions: "Where questions are asked about diseases of aging, the discussion will eventually turn toward the great scourge of age-related neurodegenerative disease. Given that sirtuins have already demonstrated potential to positively impact the aging process in a wide range of animals, it seems logical to ask whether they might also have therapeutic or prophylactic potential against neurodegeneration. The answer may end up being murky, and rely on the specific details of the specific illness and sirtuin family member in question. Two recent papers have studied the effect of sirtuin expression (and pharmaceutical modulation of sirtuin activity) on neurodegenerative disease - and come up with two diametrically opposing answers. Why the dramatic difference in results? The answer could lie either in differences between the diseases studied or in the functions of the sirtuin family members that were targeted." There is a great deal more to learn if scientists are to successfully manipulate metabolism to good effect. There are faster paths to a future of greatly enhanced longevity.