Visualizing the Biochemistry of Aging
Via GrailSearch, a look at aging from Legendary Pharmaceuticals, a company working on AGE-breakers. Don't miss the huge diagram of aging biochemistry: "Human life is supported by a complex network of biochemical substances and reactions which affect the physical state and vitality of the body and mind. Senescent changes can be seen in the rate and outcome of many of these reactions. However, many of these changes are secondary effects of senescence, rather than primary causes. ... John D. Furber of Legendary Pharmaceuticals has put together a visual model of aging referred to as 'The 2007 Network of Biological Interactions in Human Aging' that shows the interactions between various subcellular, cellular, extracellular matrix and organ system. This is a great representation of aging as it demonstrates no root cause but rather a network of problem areas that are interlinked. The goal of systems biology would be to flush this out in great detail allowing one to zoom in down to the specific genomic and proteomic components of aging."