Another Cancer Resistant Engineered Mouse

Via FierceBiotech, news of another gene-engineered mouse that doesn't get cancer: "researchers discovered that the Par-4 gene kills cancer cells, but not normal cells. There are very few molecules that specifically fight against cancer cells, giving it a potentially therapeutic application. ... mice born with this gene are not developing tumors. The mice grow normally and have no defects. In fact, the mice possessing Par-4 actually live a few months longer than the control animals, indicating that they have no toxic side effects. ... We originally discovered Par-4 in the prostate, but it's not limited to the prostate. The gene is expressed in every cell type that we've looked at and it induces the death of a broad range of cancer cells, including of course, cancer cells in the prostate. The interesting part of this study is that this killer gene is selective for killing cancer cells. It will not kill normal cells and there are very, very few selective molecules out there like this." You might recall the cancer-immune mice with immune systems capable of destroying tumors - work that was presented at SENS3 and is proceeding towards human trials.

Link: http://www.fiercebiotech.com/press-releases/press-release-cancer-resistant-mouse-discovered

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