Desired and Useful Cell State Transitions

Randall Parker comments on the latest work in controlling cell state: "For several years I've been expecting clever scientists to figure out ways to basically program around the limitations on embryonic stem cell research. By finding ways to turn the knobs on genetic switches in the cell it was inevitable that scientists would figure out how to make cells change state into embryonic cells. They will next find more genetic knobs to turn in order to convert embryonic cells into precisely desired cell types and they will even find ways convert between various non-embryonic cell types while totally avoiding an intermediate state where the cells are like embryonic cells. Cells are just complex state machines. The next few decades of advance in biotechnology can be seen as a series of advances in techniques for causing desired and useful cell state transitions. ... These scientists basically figured out how to apply a software patch to human cells that made them express genes that make them act like embryonic cells. Scientists have already identified these genes as active in early stage embryonic stem cells and have experimented with activating them in mouse cells. ... It seems unlikely that these cells have been pushed into a state that is exactly like the state of an embryonic stem cell. That state might have very subtle aspects that are important in ways we have not yet discovered."



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