Calorie Restriction Versus Pancreatic Cancer

EurekAlert! reports that the practice of calorie restriction reduces the risk of pancreatic cancer, in much the same way as it reduces the risk of epithelial cancers: "Prevention of weight gain with a restricted calorie diet sharply reduced the development of pancreatic lesions that lead to cancer [in] a strain of mice that spontaneously develops pancreatic lesions that lead to cancer. ... analysis points to a connection between calorie intake and a protein called Insulin-like Growth Factor (IGF)-1, with obesity increasing and calorie restriction decreasing levels of IGF-1. IGF-1 is an important growth factor known to stimulate the growth of many types of cancer cells. Inflammatory signaling proteins also were found to be reduced in the blood of the calorie-restricted mice. ... The decline in blood levels of inflammatory proteins in the calorie restricted mice makes sense [because] fat tissue is a major source of inflammatory factors such as cytokines."


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