Metabolic Rate, Mitochondria and Mammalian Lifespan

Correlations are pointers - they indicate where future research and development may best be directed. Here, researchers demonstrate a strong correlation between mammalian life span and various mitochondrial characteristics: "In animal cells, mitochondria are semiautonomous organelles [with] their own code and genome (mtDNA). The semiautonomy and restricted resources could result in occasional 'conflicts of interests' with other cellular components, in which mitochondria have greater chances to be 'the weakest link,' thus limiting longevity. ... (1) to what extent the mammalian maximum life span (MLS) is associated with mtDNA base composition? (2) Does mtDNA base composition correlate with another important mitochondria-associated variable - resting metabolic rate (RMR) - and whether they complement each other in determination of MLS? ... Analysis of 140 mammalian species revealed significant correlations ... To the authors' knowledge, it is the highest coefficient of MLS determination that has ever been reported for a comparable sample size. Taking into account substantial errors in estimation of MLS and RMR, it could mean that [this explains] most of the MLS biological variation. [This leads us to] mitochondria as a primary object for longevity-promoting interventions."

Link: http://dx.doi.org/10.1089/rej.2008.0676

Comments

Hindus say that the animals are alotted a certain number of breaths. Science says that metabolic speed determines lifespan. The shirl lives 2 or 3 years. The hummingbird for 15 years. Maybe the shirl breathes much faster. So it's lifespan is shorter.
When I breathe deeply at one breath every 3 seconds, it heals my joints, muscles, tendons, etc. much faster than normal. (Only up to a point.)
So, if I can keep the quality of life high even though I die sooner then that is worth dying at 60 instead of 90.

Posted by: clayton at April 18th, 2011 9:47 AM

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