Thoughts from grailsearch.org: "In essence, aging is not a process but rather an anti process. As DNA driven life forms, we are the sum of our gene expression driven by numerous molecular dials turning protein production up and down. As time passes though, the optimal concentration of the expressed proteins within us slowly becomes unbalanced. This imbalance leads to dysfunction, disease states and exposes us to many forms of environmental, microbial, viral and even self-induced damage. The good news is that the network of gene regulation has a tremendous amount of redundancy and fault tolerance designed into it from millions of years of evolutionary pressure which allows us to live as long as we do. From a systems perspective, how long we live is quite extraordinary, however [we're] probably getting close to pushing the limits on how far this system can perform without any assistance. Even with calorie restriction, optimal nutrition, supplementation, exercise and stress management, it's unlikely that a system with so many variables cannot lose its fidelity with the passage of this much time." Assistance means biotechnologies of repair and gene network control - which could be well underway if enough people wanted it to be well underway.