Towards a Way to Block Metastasis

Researchers are making progress towards identifying specific mechanisms that cause metastasis in cancer, and thereby find ways to shut it down, preventing the spread of cancer in the body and giving more time for the original tumor to be destroyed. From ScienceDaily: "Essential to our understanding of how metastasis develops is identification of the molecules, and characterisation of the mechanisms that regulate cell motility. Hitherto, these mechanisms have been poorly understood. ... [researchers have now] shown not only that the enzyme phospholipase C-gamma-1 (PLC-gamma-1) plays a crucial role in metastasis formation, but that down regulation of PLC-gamma-1 expression is able to revert metastasis progression. ... This is an exciting discovery. He has shown that turning off this molecule prevents metastasis. The simple fact is that if you stop metastasis, you stop cancer from killing people. We now need to focus on developing drugs that can block PLC-gamma-1."


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