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A Growing Interest in Heat Shock Proteins

A review paper from the community interested in metabolic manipulation to slow aging: "Heat-shock proteins (Hsps) are increasingly being implicated in aging phenotypes and control of life span across species. They are targets of the conserved heat-shock factor and insulin/IGF1-like signaling pathways that affect life span and aging phenotypes. Hsps are expressed in tissue-specific and disease-specific patterns during aging, and their level of expression and induction by stress correlates with and, in some instances, predicts life span. In model organisms, Hsps have been shown to increase life span and ameliorate aging-associated proteotoxicity. Finally, Hsps have emerged as key components in regulating aging-related cellular phenotypes, including cell senescence, apoptosis and cancer. The Hsps, therefore, provide a metric of individual stress and aging and are potential targets for interventions in aging and aging-related diseases." You might recall tha tthe cancer research community is also looking at how heat-shock proteins can be used to train the immune system to attack cancer cells.

Link: http://www.ncbi.nlm.nih.gov/pubmed/19394247

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