Prospects for Brain Regenerative Medicine

Will it be possible to use patient-derived cell transplants to heal the brain in much the same way as can be done with other organs? From EurekAlert!: researchers have "found that using an animal's own brain cells (autologous transplant) to replace degenerated neurons in select brain areas of donor primates with simulated but asymptomatic Parkinson's disease and previously in a motor cortex lesion model, provides a degree of brain protection and may be useful in repairing brain lesions and restoring function. ... We aimed at determining whether autografted cells derived from cortical gray matter, cultured for one month and re-implanted in the caudate nucleus of dopamine depleted primates, effectively survived and migrated. The autologous, re-implanted cells survived at an impressively high rate of 50 percent for four months post-implantation ... Researchers found that the cultured cells migrated, re-implanted into the right caudate nucleus, and migrated through the corpus callosum to the contralateral striatum. Most of the cells were found in the most dopamine depleted region of the caudate nucleus. This study replicated in primates the success the research team had previously reported using laboratory mice."



Has your Clinic involved in any clinical work on brain cells repair for TBI at this time?.

Posted by: Derick Williams at January 19th, 2012 1:26 PM

Can be done in USA for autistic children?

Posted by: Caridad C Garcia-Redzikowski at June 26th, 2012 4:38 PM

Many animals can already regenerate a lost limb such as a tail or a leg, but humans are a more complex structure and can only regenerate certain parts or their bodies, like ripped skin tissue. With further study humans might be able to regenerate like simple animals but it is not likely because humans have a unique spinal cord that makes regenerating a bit more complicated. Lots of animals can regenerate; like a flatworm can be cut up into tiny pieces and each of those pieces would then become individual worms. Most of the animals that can regenerate are either very simple organisms or amphibians. And younger animals can regenerate fast because their stem cells multiply faster..” Embryos and young animals regenerate lost parts much more readily than adults. For example, the rudimentary hind limb of a frog tadpole can be replaced while the leg of an adult frog cannot.Although Chameleons cannot regenerate there are multiple other animals that can regenerate. Flatworms can be cut into tiny pieces and each of those pieces will they become an individual worm, a starfish can break off its arm and the there will be two starfish, and crickets can regrow their broken or cut off legs. The reason these animals can regenerate and humans can’t is because they are invertebrates, a spinal cord is just too complex to regenerate.

“The exact mechanism of how these animals can regenerate is not currently well understood.”…but in the future after all the studies are done there is a possibility that humans will be able to regenerate all if not most of their body parts. Since there really has not been much study on this case the possibilities can vary, and it is a probable assumption that humans will be able to regenerate more than just the simple parts we can do now.
Recent research has proven that cells can regenerate in multiple parts of the brain but not all. The University of Princeton has discovered that new neurons can be added to the brain of adult monkeys. Scientists are surprised by this new discovery because they always thought that when they found regenerating cells it would be in smaller parts of the brain but the added neurons are in the cerebral cortex, which is one of the more complicated and efficient parts of the brain. Scientist found this regeneration in three parts of the monkey’s brain and that shows vital information because a monkey is one of the closest animals that react like a human so if the studies in monkeys enhance pretty soon humans will be able to regenerate too.
“Researchers are optimistic that with further study scientists might one day unlock the key to this process of brain cell growth and use the knowledge to treat a variety of brain disorders and diseases.”
Stem cells are always multiplying but mostly when you’re a child. If a child’s stem cell is transmitted into an adult the stem cell would multiply until there were enough stem cells to regenerate the broken or ill area. Scientist have found a way to manipulate stem cells and because of this many diseases and broken tissues can be fixed in the future. We’ve already made great progress…“With this patient we've actually regrown a jawbone that is identical to the one he lost”…If later in the future we can manipulate stem cells to go into our blood stream and circulate throughout our whole body than in theory any broken bones, tissue, cuts, or even scrapes would heal themselves without any sort of treatment or physical therapy.

Posted by: Adam Levien at March 9th, 2013 2:23 PM

I would to hear of any research being done on regenerative medicine related to damaged occipital lobes.

Posted by: Elizabeth Sage at March 17th, 2013 5:19 PM

Does it work well with stork victoms, and how?

Posted by: Bea Cahenzli at April 13th, 2014 9:53 AM

Bea Cahenzli,
Research the term "Papal Cure" for stroke victims. It's the newest stem cell technology available for stroke patients using their own stem cells.

Posted by: PJ P at July 21st, 2014 1:10 PM

Post a comment; thoughtful, considered opinions are valued. New comments can be edited for a few minutes following submission. Comments incorporating ad hominem attacks, advertising, and other forms of inappropriate behavior are likely to be deleted.

Note that there is a comment feed for those who like to keep up with conversations.