Evolution and Gender Longevity Differences
This particular researcher is somewhat fixated on TOR (when all you have is a hammer...) but this open access paper provides an interesting set of ideas on why men and women have differing life expectancies: "Women have lived longer than men in different countries and in every era ... Yet, it is believed that men do not age faster than women but simply are weaker at every age. In contrast, I discuss that men [do] age faster. From [an] evolutionary perspective, high accidental death rate in young males is compatible with fast aging. Mechanistically, hyper-activated mTOR (Target of Rapamycin) may render young males robust at the cost of accelerated aging. But if women age slower, why then is it women who have menopause? Some believe that menopause is programmed and purposeful (grandmother theory). In contrast, I discuss how menopause is not programmed but rather is an aimless continuation of the same program that initially starts reproduction at puberty. This quasi-program causes over-activation of female reproductive system, which is very vulnerable to over-activation."
Link: http://www.impactaging.com/papers/v2/n5/full/100149.html