Fight Aging!

In the fantasy land where you have control over a large sum of money, millions or tens of millions of dollars, how would you spend it to best advance the state of longevity science - to bring forward the age of greatly extended healthy human lives? You can't take it with you, after all. In this life, the only rational use for large sums of money is longevity science; all else is fleeting and soon enough dust and ashes.

A hundred years ago, additional time was a limited commodity. You could spend resources to have a little more of it - doctors, a good life, the learning needed to take advantage of these items - but after a certain point there was no amount you could spend that would let you live for even one additional day. This is no longer the case. A sufficiently massive directed research program could, for example, realize the SENS program for rejuvenation within a couple of decades, to produce the planned and presently understood methods for repairing the biochemical and cellular damage that causes aging.

So what would you spend your fantasy millions on? How would you invest in research? This question is something of a litmus test: you can't answer it without sharing your opinions on what is important and what is not in present day aging science, related biotechnologies, and strategies for application or commercialization.

I see that Maria Konovalenko has thoughts on this topic:

4. Research in increasing cryoprotectors efficacy - $3 million
5. Creation and realization of a program 'Regulation of epigenome' - $5 million
6. Creation, promotion and lobbying of the program on research and fighting aging - $2 million
7. Educational programs in the fields of biogerontology, neuromodelling, regenerative medicine, engineered organs - $1.5 million
8. 'Artificial blood' project - $2 million
9. Grants for authors, script writers, and art representatives for creation of pieces promoting transhumanism - $0.5 million
10. SENS Foundation project of removing senescent cells - $2 million

Now for my part I think what is most needed today is a demonstrated success in the application of SENS research. Something that works to extend life in mice by repairing one of the forms of biochemical damage catalogued by Aubrey de Grey, and that we can all point to as an example of how longevity science should be done - a magnet for future fundraising, and validation for repair-based approaches to human longevity in the eyes of people yet to be convinced.

So, given that, I wouldn't spread my non-existent large sum of money around between many different classes of project. I put it all into one of the SENS research themes most likely to achieve a good result soon. For $30 million, I'd probably go for biomedical remediation of the unwanted biochemicals that build up and degrade our metabolism. A great deal of this work is discovery: sifting soil for microbes that can digest the gunk that our bodies cannot break down, and then performing many, many low-cost chemical tests in parallel to find useful bacterial enzymes. $30 million will buy you coverage of a large swath of the possible search space, followed by tests in aged mice to demonstrate improvement in measurable biomarkers of health following treatment with the most promising candidates.

A working method of biomedical remediation that improved measures of mouse health by eliminating the build-up of otherwise persistent metabolic byproducts would be exactly a form of limited rejuvenation. That would be big news.