From Nanowerk: "Chemotherapeutics generally show a delicate balance between maintaining a high enough dose to kill cancer cells while avoiding a dose so high that it causes severe toxic effects. One of the many promises of nanomedicine is a class of nanoscale drug delivery vehicles that can pinpoint cancer cells and deliver their tumor-killing payload right into cancer cells with high efficiency and no side effects. As an example of how scientists are approaching this goal, [we] have provided a first report on in vivo cancer therapy with mesoporous hollow silica nanomaterials. Based on this novel silica nanorattle structure, the Chinese research team further extended their work to fabricate 'all-in-one' multifunctional gold nanoshells on silica nanorattles (GSNs) which combine remote-controlled photothermal therapy with chemotherapy - resulting in a 'magic bullet' to kill cancer cells. The results indicate that a combination of hyperthermia and chemotherapeutic agents is an encouraging approach to optimizing cancer therapy for the synergistic effects are greater than the two individual treatments alone. ... GSNs are a promising building block with many biomedical applications, such as biological imaging, thermal ablative cancer therapy and immunoassays. Due to the specific silica nanorattle core, GSNs are also promising as a versatile and multifunctional drug delivery platform for their high-payload delivery of various drugs into their targets."