Fight Aging!

Long-lived naked mole-rats exhibit fairly large systematic differences in longevity within the species, and understanding the mechanisms may point the way to a class of therapies for aging: "African mole-rats (Bathyergidae, Rodentia) contain several social, cooperatively breeding species with low extrinsic mortality and unusually high longevity. All social bathyergids live in multigenerational families where reproduction is skewed towards a few breeding individuals. Most of their offspring remain as reproductively inactive 'helpers' in their natal families, often for several years. This 'reproductive subdivision' of mole-rat societies might be of interest for ageing research, as in at least one social bathyergid (Ansell's mole-rats Fukomys anselli), breeders have been shown to age significantly slower than non-breeders. These animals thus provide excellent conditions for studying the epigenetics of senescence by comparing divergent longevities within the same genotypes without the inescapable short-comings of inter-species comparisons. It has been claimed that many if not all social mole-rat species may have evolved similar ageing patterns, too. However, this remains unclear on account of the scarcity of reliable datasets on the subject. We therefore analyzed a 20-year breeding record of Giant mole-rats Fukomys mechowii, another social bathyergid species. We found that breeders indeed lived significantly longer than helpers (ca. 1.5 - 2.2fold depending on the sex), irrespective of social rank or other potentially confounding factors."

Link: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0018757