Nitric Oxide and Aging Blood Vessels

Nitric oxide levels are a possible target for therapies aimed at some of the signs of aging in blood vessels: "Many disorders emerge with advancing aging, and cardiovascular diseases (CVD) are a major cause of morbidity and mortality in the elderly. The term vascular aging encompasses all the structural and functional alterations in the blood vessels with progressive aging. Both smooth muscle cells and intima layers are affected. These vascular changes lead to endothelial dysfunction, arterial stiffness in consequence of intense remodeling and calcification, impaired angiogenesis, greater susceptibility to vascular injury and atherosclerotic lesions. The mechanisms underlying vascular aging are complex and involve multiple pathways and factors ... In this complex scenario, vascular function depends on the balanced production/bioavailability of nitric oxide (NO), which is maintained by the normal activity of endothelial nitric oxide synthase (eNOS). On the other hand, excessive amount of NO produced by inducible nitric oxide synthase (iNOS) up-regulation contributes to vascular dysfunction. Evidence obtained from experimental models indicates that decreased NO bioavailability as well as increased reactive nitrogen species (RNS) production contributes to aging-associated vascular dysfunction. ... Pharmacological modulation of NO generation and expression/activity of NOS isoforms may represent a therapeutic alternative to prevent the progression of cardiovascular diseases."

Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382417/

Comments

On page 3 of the full text paper, the authors state that high nitrite diets increase NO production, decrease blood pressure and may be responsible for the beneficial effects of the Japanese diet.

Perhaps this could be checked by a survey of mouthwash use.
Anti-microbial mouthwashes destroy the oral bacteria that are required for nitrite absorption. Those who use mouthwashes regularly might not benefit from a high nitrite diet (beets, spinach,...)

Posted by: Lou Pagnucco at July 5th, 2012 8:10 AM

Perhaps also worth noting is that NO, along with TNF-alpha, may drive aging of skin and vascular cells by propelling stem cells along their differentiation trajectory faster. See:

"Grainyhead like 3 – a newly identified TNFalpha regulated
transcription factor – is regulated by the Src kinases & NO"
http://www.biomedcentral.com/content/pdf/1478-811X-7-S1-A63.pdf

"The key (proteins) to self-renewing skin"
http://medicalxpress.com/news/2012-07-key-proteins-self-renewing-skin.html

Posted by: Lou Pagnucco at July 6th, 2012 10:36 AM

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