Longer Telomeres, Less Cancer in Calorie Restricted Mice

Here's one of the hundreds of examples to show that the practice of calorie restriction improves near all measures of health and slows near all measures of aging:

To carry out the study, researchers used young mice - just three months old - and reduced their caloric intake by 40% before observing them until the end of their life cycle. "We see that mice that undergo caloric restriction show a lower telomere shortening rate than those fed with a normal diet. These mice therefore have longer telomeres as adults, as well as lower rates of chromosome anomalies."

To study the effects of this phenomenon on the health of the mammals, researchers observed the incidence of age-related illnesses like cancer. The mice that had been fed a lower calorie intake showed a reduction in the incidence of cancer. Furthermore, these mice also showed a lower incidence of other age-related illnesses such as osteoporosis, greater glucose uptake or improvements in motor coordination.

When the researchers carried out these same experiments with a variety of mice that produce more telomerase - a protein that lengthens telomeres and protects chromosomes - they observed that these mice not only enjoyed better health but also lived up to 20% longer. "We believe that such a significant increase in longevity is due to the protective effect against cancer produced by caloric restriction - incidences fall by 40% if we compare them with the mice that produce more telomerase and have a normal diet - and, added to the presence of longer telomeres, this makes the mice live longer and better."

It is calculated that there are currently more than 10,000 people in the world on some form of controlled caloric restriction, so the observation of these individuals will be decisive in discovering the effects of this type of diet on humans.

Link: http://www.eurekalert.org/pub_releases/2013-01/cndi-crh012313.php

Comments

There's been some speculation that telomerase could promote cancer, hasn't there? I realize that this isn't really a properly controlled experiment on telomerase as such, but it seems worth noting.

Posted by: Brandon Berg at January 24th, 2013 12:01 PM

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