Treating Traumatic Brain Injury With Stem Cells

Here is one example drawn from many ongoing lines of research aimed at the development of stem cell treatments for a broad variety of injuries. Enhanced regeneration will be a strong theme in the new medical technologies of the next two decades:

A stem cell therapy previously shown to reduce inflammation in the critical time window after traumatic brain injury also promotes lasting cognitive improvement, according to preclinical research. Cellular damage in the brain after traumatic injury can cause severe, ongoing neurological impairment and inflammation. Few pharmaceutical options exist to treat the problem. About half of patients with severe head injuries need surgery to remove or repair ruptured blood vessels or bruised brain tissue.

A stem cell treatment known as multipotent adult progenitor cell (MAPC) therapy has been found to reduce inflammation in mice immediately after traumatic brain injury, but no one had been able to gauge its usefulness over time. [Researchers here] injected two groups of brain-injured mice with MAPCs two hours after the mice were injured and again 24 hours later. One group received a dose of 2 million cells per kilogram and the other a dose five times stronger.

After four months, the mice receiving the stronger dose not only continued to have less inflammation - they also made significant gains in cognitive function. A laboratory examination of the rodents' brains confirmed that those receiving the higher dose of MAPCs had better brain function than those receiving the lower dose. "Based on our data, we saw improved spatial learning, improved motor deficits and fewer active antibodies in the mice that were given the stronger concentration of MAPCs."



How many progenitor cells can you make in an hour? Head trauma usually happens without warning, so delivering a lot of new cells in two hours may be difficult.

I suspect current treatment of head trauma is appallingly bad, and they make no effort to deliver essential brain nutrients. So I really hope this can be used on humans.

Posted by: Carl at November 6th, 2013 8:29 AM

Carl is correct. The NHS still ( so far as I am aware ) do not routinely inject Progesterone into TBI patients..recommended practice for at least 8 years.

Stem Cell Therapy post long-term TBI should be the aim. Many servicemen and my son hopefully will benefit one day.

Posted by: Mike at November 7th, 2013 6:18 AM
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