The Major Mouse Testing Program: Aiming to Speed Progress in Longevity Science

The Major Mouse Testing Program is a non-profit initiative setting up to run life span studies for potential age-slowing treatments that the rest of the research community isn't going to get to any time soon. The gold standard of life span studies are those carried out by the Interventions Testing Program at the NIA, but that group is poorly funded, slow, and conservative in their choices. The ITP staff won't be testing senolytic drug candidates or combinations of everything shown to modestly slow aging in mice any time soon, for example. So there is room for others to cut to the chase:

The field of regenerative medicine is becoming increasingly important for the future of healthcare and even how we view aging. With stem cell technology, gene therapy and other longevity technology on the horizon humanity can finally consider living longer, healthier lives. Some drugs already tested have been found to increase mouse lifespan such as metformin and rapamycin. These drugs are even now moving into human clinical trials to see if the above benefits translate into people. However, there are many more promising substances that have never been properly tested and we do not know if they could extend healthy lifespan. How fast science advances depends on how much quality research is being conducted. Currently there are few high impact studies investigating lifespan initiated each year ­ and with so many promising substances to test this is all a painfully slow process. The Major Mouse Testing Project (MMTP) is aiming to help by rapidly testing compounds and speeding up progress.

A significant problem with longevity research and testing in the past has been a lack of robust results. Small animal cohorts and questionable husbandry, combined with poor metrics or protocols, have lead to inconsistent or even conflicting results. In a field as poorly funded as longevity research currently is, we cannot afford to waste money and effort on flawed experiments that do not provide solid evidence of efficacy and high potential for human clinical trials. The Major mouse testing program is working to redress this situation with the help of an international team of dedicated researchers. We hope to deliver the kind of consistent and quality data required to provide definite confirmation of longevity interventions. We plan to initiate large scale testing on already aged mice - the approximate equivalent of a human aged sixty. This means we can produce consistent, accurate and notably faster results to drive progress.

It is also plausible that some interventions, when combined, could have a synergy where the effects are greater than the individual compounds, such as the case with dasatinib and quercetin for the clearance of senescent cells. It is possible there are more synergies to be discovered and this is where the MMTP plans to push forward, not only testing single interventions but also in testing combinations to seek out these powerful synergies. Our researchers are working on a practical solution to test these combinations and at the same time hope to provide the kind of accurate data science demands to prove efficacy.

Link: https://www.singularityweblog.com/the-major-mouse-testing-program/

Comments

@reason: You are making me blush :) Thanks for noticing us we are pushing really hard to engage the community worldwide at the moment, trying to meet thought leaders, transhumanist leaders and advocacy groups.

We are looking for people to help with our teams too if anyone is interested, drop us a line at info@majormouse.org

I will keep you posted on developments.

Posted by: Steve H at January 13th, 2016 10:28 AM

Si los organos de un joven de 15 años reciben poco daño, aún cuando tiene la misma genética, alimentación y medio ambiente que cuando es adulto, esto podría deberse a un funcionamiento casi perfecto del sistema inmune, que no sólo reaccionaría ante enfermedades, sino también ante desechos celulares que el cuerpo no puede procesar, como los que forman las placas dentros de las arterias, los dañinos oxidantes resultantes de la dieta o excedentes de células muertas o defectuosas, etc.. De ser este el caso, reparar el sistema inmune debería significar un cambio importante a realizar en vías de mejorar la salud.

Posted by: eduardo at January 13th, 2016 3:50 PM

Post a comment; thoughtful, considered opinions are valued. New comments can be edited for a few minutes following submission. Comments incorporating ad hominem attacks, advertising, and other forms of inappropriate behavior are likely to be deleted.

Note that there is a comment feed for those who like to keep up with conversations.