How Great is the Dormant Potential for Regeneration in Tissues?

Over the years numerous research groups have claimed the existence of novel stem cell or stem cell like populations in various tissues. Stem cells spend much of their time dormant, but with the right signals or other form of control, it is plausible that they could be directed to greater activity, enhancing tissue regeneration. This is a slow process of discovery, however, usually accompanied by debates over whether or not cells of a claimed type actually exist, whether the research methodologies used in published studies are sound, and so forth. It is wise not to become too excited over any specific claim, but the prevalence of this sort of research suggests that there may be something there. The results noted here are an example of the type, in this case for the central nervous system. The potential to induce regeneration of nerve tissue and the brain is a topic of great interest in the research community.

A major goal of regenerative research is to repair the brain efficiently following injury, for example due to stroke, Alzheimer's disease or head trauma, disease or ageing. The brain is poor at repairing itself; however, it may become possible to improve repair without surgery by targeting stem cells residing in patients' brains. Stem cells have the unique capacity to produce all of the cells in the brain but are normally kept inactive in a form of cellular 'sleep' known as quiescence. Quiescent cells do not proliferate or generate new cells. Thus, any regenerative therapy targeting stem cells must first awaken them from quiescence.

Researchers now report the discovery in the brain of a new type of quiescent stem cell (known as 'G2 quiescent stem cell') with higher regenerative potential than quiescent stem cells identified previously. Importantly, G2 quiescent stem cells awaken to make the key types of cell in the brain - neurons and glia - much faster than known quiescent stem cells, making them attractive targets for therapeutic design. "The brain is not good at repairing itself, but these newly-discovered stem cells suggest there may be a way to improve its ability. These stem cells are in a dormant state, but once awake, they have the ability to generate key brain cells."

By studying the fruit fly (Drosophila), the authors identified a gene known as tribbles that selectively regulates G2 quiescent stem cells. The DNA of fruit flies has many similarities with that of humans, making them a useful model to understand human biology, and 60% of human genes associated with disease are also found in Drosophila. The tribbles gene has counterparts in the mammalian genome that are expressed in stem cells in the brain. The researchers believe that drugs that target tribbles might be one route to awakening G2 quiescent stem cells. "We've found the gene that directs these cells to become quiescent. The next step is to identify potential drug-like molecules that block this gene and awaken a person's stem cells."



Tribbles is an appropriate name for a gene that may enable stem cells to be replicative active again. Hopefully the restored replication will not be as uncontrolled as that of the Tribbles in Star Trek.

Posted by: Abelard Lindsey at April 6th, 2018 10:58 AM

I had an older relative about 80 who had a stroke, and the Dr. said she would never recover leg and arm movement she had lost. However, she recovered fully within a month, and I believe it was a matter of waking up these quiescent stem cells that allowed the recovery.

Posted by: Biotechy at April 7th, 2018 7:48 AM

I dunno, a gene labelled 'tribbles' invokes quite scary, cancerous connotations. It sounds like something you'd name a super-potent oncogene, which if activated results in cell replication so rapid that that before you know it, you have tumours the size of elephants.

Posted by: Arcanyn at April 7th, 2018 1:27 PM

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