Promising Long Term Results in Stem Cell Therapy for Peripheral Artery Disease
Five years ago, a small group of patients who had exhausted other treatment options for their peripheral artery disease were treated with stem cells. Researchers have followed the patients since then, and here report on the long term results - they are promising. This is also the case for a range of other comparatively simple stem cell transplant therapies, now that the research and medical communities have had years to practice and refine the methodologies involved.
A long-term study of patients who received stem cells to treat angiitis-induced critical limb ischemia (AICLI) shows the cells to be both safe and effective. The study could lead to an option for those who suffer from this serious form of peripheral arterial disease (PAD). AICLI is caused by an inflammation of the blood vessels that leads to a severe blockage in the arteries of the lower or upper extremities. It causes severe pain and impaired mobility, and can even lead to amputation and death. While endovascular and surgical reconstruction are the mainstream treatments for critical limb ischemia (CLI), these classical treatments are unfeasible in approximately 15 to 20 percent of patients.
Stem cell therapy is a promising option for these otherwise no-option CLI patients. As one of the promising stem cell therapies, purified CD34+ cell transplantation (PuCeT) has shown favorable short-term results, but prior to this new study no one had looked at its long-term outcome. Researchers tracked 27 AICLI patients for five years after each had received an intramuscular injection of PuCeT to treat their disease. The primary endpoint - major-amputation-free survival rate - as well as secondary endpoints such as peak pain-free walking time and the scale of the patient's pain, were routinely evaluated during the five-year follow-up period.
The results showed that the major-amputation-free survival rate of these patients was 88.89%, the pain free walking time increased nearly 6-fold and the level of pain they experienced was reduced by more than half. Notably, in 17 patients (65.38 percent) not only were their limbs saved, but they also fully recovered their labor competence and returned to their original jobs by week 260.
Link: https://www.eurekalert.org/pub_releases/2018-05/w-scs050118.php
I'd just like to note that this is a pathology-oriented study, which allows them to use the unaffected general population as a control. What we need is studies focused on enhancement. Here is a hypothesis for an equivalent wellness study. Do you remember the fitness icon Jake Lellane? He lived to 96. I think it is possible that his weight training was bone-bending and squeezing stem cells out of his marrow more that the general population.
Is there any way to get a study of the contents of the blood and other fluids being released from bones during intensive weight training?
@Tom
"Current evidence that exercise can increase the number of adult stem cells"
https://link.springer.com/article/10.1007/s10974-012-9302-0
"Exercise increases neural stem cell number in a growth hormone-dependent manner, augmenting the regenerative response in aged mice"
https://www.ncbi.nlm.nih.gov/pubmed/19544415
My thought is that regular exercise stimulates the stem cell pools in the bone marrow of the large leg bones, by providing increased blood flow to the bone marrow, and also aiding housekeeping activities throughout the body.