The LEAF Rejuvenation Roadmap

The Life Extension Advocacy Foundation (LEAF) volunteers have started to maintain a Rejuvenation Roadmap resource. This is intended to be a reference and visual summary of the state of progress in the various lines of research the LEAF staff consider relevant to the treatment of aging as a medical condition. We can always disagree on the details, such as the choice to use the Hallmarks of Aging rather than SENS as a categorization strategy, but I think that this sort of project is very helpful as our community grows. New arrivals benefit greatly from summaries and starting points. In the years ahead the present set of disagreements found in summaries of the field and strategic choices in research should be washed away by data from clinical trials - questions of what works and what doesn't will start to have firm answers.

One of the most commonly asked questions we receive is "How is progress going in aging research?" It is something we are asked so often that we decided to provide the community with a resource that will help them to keep track of progress directly. To that end, today we have launched our new curated database, the Rejuvenation Roadmap, which will be tracking the progress of the many therapies and projects in the rejuvenation biotechnology field. This database aims to give a quick visual summary of the status of each drug or therapy along with some additional information for people interested in learning more about them.

We believe that an informed community is an effective one, and this was one of our motivations for developing this new database. There are many resources for scientists, such as the superb databases of the Human Ageing Genomic Resources maintained by Dr. João Pedro de Magalhães, which are excellent for researchers. However, we noticed that there was no database that tracked the efforts of the many researchers and projects in the field, and while some people do maintain lists, they are often not public facing, easy to access, or user-friendly.

Obviously, this is very much a work in progress, and the current list of therapies is relatively small, but it does give an idea of how it will work, and it is not hard to see how this could grow into a comprehensive resource for the community. The database will continue to grow and be updated as time passes, giving a unique, up-to-date overview of where the science and progress currently is. We hope that you like what we are doing with The Rejuvenation Roadmap and that you will find it useful.



Cheers Reason and glad you like it. Early days for the database but we will add many more as we go along and develop this. Expect a surge after our July 12th conference is over.

Posted by: Steve Hill at June 12th, 2018 7:17 AM

I've often thought it might be cool if the fightaging/leafscience blog articles were organised on horizonatal bars for each SENS/Hallmarks category with chronological order of the articles going from left to right.

Then again, it may not be that much use?

Posted by: Jim at June 13th, 2018 3:57 AM

btw I am not suggesting abandoning the tradition wall of text blog style, just having the archives page set up in the horizontal bars style.

Posted by: Jim at June 13th, 2018 4:56 AM

@Jim we use tags and categories on the blog to help people search for the damages and hallmarks. We list both SENS and Hallmarks categories as well. Obviously, a few of them overlap anyway.

Ichor and others are being added to the Roadmap soon, got a backlog of new ones to add so this is going to grow a lot. I am going to add a filter in hopefully so it is manageable.

Posted by: Steve Hill at June 13th, 2018 5:14 AM

That's super useful Steve, great initiative !

It allowed me to learn that MSC was even farther in the labs than senolytics.

Posted by: Spede at June 13th, 2018 7:09 AM


If I want to review or get updates on an aging topic, I typically just use the FA blog search box to get a start, then on to PubMed if I want more. Now I'll probably also begin with a visit to the LEAF Roadmap page.

Posted by: CD at June 13th, 2018 10:22 AM

Thanks Steve, love the status chart. Very easy to see progress of each one. You and LEAF do a great service to the longevity community and though the world largely don't know it yet, the world.

Posted by: Robert at June 13th, 2018 1:29 PM

Thanks for the support folks we appreciate it a lot. We will be adding a host more projects soon including LysoCLEAR and others.

Posted by: Steve Hill at June 14th, 2018 6:13 AM

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