Antioxidant Effects of Stem Cell Exosome Therapy

Oxidative stress is the excessive generation of oxidizing molecules in tissues, which can cause a range of harms, reacting with important molecular machinery to harm cells and detrimentally alter cell function. Rising oxidative stress goes hand in hand with the chronic inflammation of aging; some of the underlying mechanisms are shared. Thus researchers find that therapies that alter cell behavior to reduce chronic inflammation, such as stem cell transplants and the use of exosomes derived from those stem cells, may also act to reduce oxidative stress in aged tissues.

Mesenchymal stem cell-derived exosomes have been under investigation as potential treatments for a diverse range of diseases, and many animal and clinical trials have achieved encouraging results. However, it is well known that the biological activity of the exosomes is key to their therapeutic properties; however, till date, it has not been completely understood. Previous studies have provided different explanations of therapeutic mechanisms of the exosomes, including anti-inflammatory, immunomodulatory, and anti-aging mechanisms.

The pathological effects of oxidative stress often include organ damage, inflammation, and disorders of material and energy metabolism. The evidence gathered from research involving animal models indicates that exosomes have antioxidant properties, which can also explain their anti-inflammatory and cytoprotective effects. In this study, we have summarized the antioxidant effects of exosomes in in vivo and in vitro models, and have evaluated the anti-oxidant mechanisms of exosomes by demonstrating a direct reduction in excessive reactive oxygen species (ROS), promotion of intracellular defence of anti-oxidative stress, immunomodulation by inhibiting excess ROS, and alteration of mitochondrial performance.

Exosomes exert their cytoprotective and anti-inflammatory properties by regulating the redox environment and oxidative stress, which explains the therapeutic effects of exosomes in a variety of diseases, mechanisms that can be well preserved among different species.



Exosomes are quite interesting but at several thousand dollars an infusion for the good ones they would need to make long term improvements. Has anyone seen that?

Posted by: august33 at January 7th, 2022 8:51 PM

No need for an infusion. Can be taken orally. Probably works better orally.

Posted by: JLH at January 8th, 2022 4:00 PM

At august: At different times, I have had exosomes in my left knee, allogeneic MSCs in my right knee, both were effective in helping me repair osteoarthritis over the course of a month. That was about 16 months ago. I suspect I will need another treatment in 12-20 month as osteoarthritis is a recurring condition

Posted by: JohnD at January 9th, 2022 9:10 PM
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