Taurine Supplementation Slows Aging, Extends Life in Mice

Taurine levels drop with age, and correlate with health in aged humans. Researchers here show evidence for taurine supplementation to improve health and extend life span in mice. While it isn't mentioned in this paper, if one takes a look around the literature on this topic, taurine may act on the pace of aging by increasing levels of the antioxidant enzyme glutathione, and has been shown to diminish oxidative stress. You may recall that supplementation with glutathione precursors has been shown to improve health in both old mice and old humans. Glutathione itself is harder to deliver directly, hence the more indirect strategies. The observed effects on health and life span may be due to improved mitochondrial function, reducing the dual impact of mitochondrial dysfunction: loss of ATP production needed to power cell processes on the one hand, and and excessive production of oxidative molecules that can damage molecular machinery elsewhere in the cell on the other.

Aging is associated with systemic changes in the concentrations of molecules such as metabolites. However, whether such changes are merely the consequence of aging or whether these molecules are drivers of aging remains largely unexplored. If these were blood-based drivers of aging, then restoring their concentration or functions to "youthful" levels could serve as an antiaging intervention. Taurine, a semiessential micronutrient, is one of the most abundant amino acids in humans and other eukaryotes. Earlier studies have shown that the concentration of taurine in blood correlates with health, but it is unknown whether blood taurine concentrations affect aging. To address this gap in knowledge, we measured the blood concentration of taurine during aging and investigated the effect of taurine supplementation on health span and life span in several species.

Blood concentration of taurine declines with age in mice, monkeys, and humans. To investigate whether this decline contributes to aging, we orally fed taurine or a control solution once daily to middle-aged wild-type female and male C57Bl/6J mice until the end of life. Taurine-fed mice of both sexes survived longer than the control mice. The median life span of taurine-treated mice increased by 10 to 12%, and life expectancy at 28 months increased by about 18 to 25%. A meaningful antiaging therapy should not only improve life span but also health span, the period of healthy living. We, therefore, investigated the health of taurine-fed middle-aged mice and found an improved functioning of bone, muscle, pancreas, brain, fat, gut, and immune system, indicating an overall increase in health span.

Investigations into the mechanism or mechanisms through which taurine supplementation improved the health span and life span revealed that taurine positively affected several hallmarks of aging. Taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammation. An association analysis of metabolite clinical risk factors in humans showed that lower taurine, hypotaurine, and N-acetyltaurine concentrations were associated with adverse health, such as increased abdominal obesity, hypertension, inflammation, and prevalence of type 2 diabetes. Moreover, we found that a bout of exercise increased the concentrations of taurine metabolites in blood, which might partially underlie the antiaging effects of exercise.

Link: https://doi.org/10.1126/science.abn9257


Taurine does look pretty promising. It appears to make histone related methylation go to a more youthful status at H3k27 etc. And just like NAD+ and AKG the levels in the body start dropping a lot in the later 30s.

Posted by: Mike Best at June 16th, 2023 8:12 AM

At the daily dose of 1g/kg of body weight, this is beyond what and reasonable person would consider to a supplement. It is a large change to the diet macros.

Posted by: JohnD at June 16th, 2023 9:01 AM

This is at least the 4th time I came across a medical article THIS WEEK on Taurine. I ordered it earlier this week from Amazon. Glad you put it in your blog, Reason. I respect your opinions on medical issues more than most.

Posted by: Robert at June 16th, 2023 12:10 PM

Ooh... another study saying that mice live longer if you pimp their shitty redox system with anti-oxidents. Ooh... M. Kaeberlein is involved . Is his rapamycin business struggling?

'The median life span of taurine-treated mice increased by 10 to 12%.'
The reported effect size is even worse than interventions like taking a walk or putting the fork down every now and then. LOL!

Posted by: Jones at June 17th, 2023 5:41 AM

The human equivalent dosage is 3,000-5,000 mg.

Some previous studies show that daily taurine intake of 300mg significantly reduces the risk of adult diseases such as diabetes and heart attacks.


Posted by: AmadeusJpn137 at June 18th, 2023 12:13 AM
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