Attacking Breast Cancer Stem Cells

Via the Detroit News: "trials are being conducted on women with advanced stage breast cancer and attempt to target the cancer's stem cells, which are believed to be resistant to traditional therapies and the fuel behind cancer's spread. By using experimental drugs to block these cancer stem cells, doctors hope the tumors will shrink or at least stop spreading and will lead to better ways to treat - and possibly cure - the disease that is the nation's second-leading cause of death. ... We rarely use the 'C word' - cure - but the intent of research today is not to study (cancer) but to treat and ultimately to beat it. There is so much hope that we're positioned today with the information from the (human) genome, with the biologic expertise and understanding of the stem cells, I think we can be at the vanguard of treatments that hopefully will lead toward not just longer, disease-free survival but quite literally cures. That's the hope of the cancer stem cell approach. ... In breast cancer, we have very good results of getting rid of the primary cancer with surgery or radiation therapy but what is lethal to a number of women who actually die of breast cancer is the spread of the cancer. These cancer stem cells are the cells that are metastatic. That's why we had to develop new approaches to target these cancer stem cells if we are going to cure more women with breast cancer and other types of cancer."

Link: http://www.detnews.com/article/20100930/METRO/9300421/U-M-stem-cell-trial-promising

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