Towards Stem Cell Therapy for Macular Degeneration

Small steps: "The notion of transplanting adult stem cells to treat or even cure age-related macular degeneration has taken a significant step toward becoming a reality. ... researchers have demonstrated, for the first time, the ability to create retinal cells derived from human-induced pluripotent stem cells that mimic the eye cells that die and cause loss of sight. Age-related macular degeneration (AMD) [gradually] destroys sharp, central vision needed for seeing objects clearly and for common daily tasks such as reading and driving. AMD progresses with death of retinal pigment epithelium (RPE), a dark color layer of cells which nourishes the visual cells in the retina. While some treatments can help slow its progression, there is no cure. The discovery of human induced pluripotent stem (hiPS) cells has opened a new avenue for the treatment of degenerative diseases, like AMD, by using a patient's own stem cells to generate tissues and cells for transplantation. For transplantation to be viable in age-related macular degeneration, researchers have to first figure out how to program the naïve hiPS cells to function and possess the characteristics of the native retinal pigment epithelium, RPE, the cells that die off and lead to AMD. ... This is the first time that hiPS-RPE cells have been produced with the characteristics and functioning of the RPE cells in the eye. That makes these cells promising candidates for retinal regeneration therapies in age-related macular degeneration."

Link: http://www.eurekalert.org/pub_releases/2011-03/gumc-sct031811.php

Comments

Good information about the AMD
please help us to know when the stem cell treatment will be started
were we avail this treatment

Posted by: vittal reddy at March 28th, 2011 11:02 AM

Please let me know if there is anywhere to get treatment at this time. All the literature indicates stem cell treatment for AMD is still at the research level. I have a family member that would be interested in actual treatment.

Please get back to me as soon as you can.

Thanks.

Posted by: Marilyn Stiegler at May 29th, 2011 11:43 AM

I believe that the best way to get treatment presently is participation in trials. Here's a link to a past post discussion how to go about researching entry into a trial:

https://www.fightaging.org/archives/2004/11/researching-therapies-and-participation-in-trials.php

And a search of clinicaltrials.gov shows:

http://www.clinicaltrials.gov/ct2/results?term=stem+cells+macular

Which isn't saying much, unfortunately - there are not many trials taking place. I'm not aware of any reputable overseas clinics offering stem cell therapies for AMD at this time, and as you say, it's still at the research level.

Posted by: Reason at May 29th, 2011 1:16 PM

Having been told i have MD at 46 ,was quite a shock , how can i get on a clinical trial for this.

Posted by: Tina Nash at December 5th, 2011 11:19 AM

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