If Nothing is Done, Sarcopenia Incidence Will Increase Greatly

Researchers here predict future incidence of sarcopenia, the loss of muscle mass and strength that occurs with aging and that is one of the main components of age-related frailty. As the average age of a population rises, incidence, costs, and burden on health will increase, and the costs at least have been something of a concern in political circles in recent years. There is some value in projecting present trends in epidemiology to create dire warnings on future prevalence of age-related disease, even though these trends are already out of date given what is going on in the labs and in early trials. It is a way to increase support for ongoing research to treat and prevent age-related disease, or ideally to intervene in the underlying processes that cause aging, and research funding always needs all the help it can get. In the case of sarcopenia, potential treatments include myostatin inhibition through gene therapy - or other less permanent methods - to spur more muscle growth than would otherwise occur, something that has already shown considerable potential in early human trials, and for which a large body of animal study data exists.

Sarcopenia is a disease associated with the ageing process. Hallmark signs of the disorder are loss of muscle mass and strength, which in turn affects balance, gait and overall ability to perform tasks of daily living. Due to its complexity, there is as yet no global consensus on the definition of the disease for diagnostic purposes. The European Working Group on Sarcopenia in Older People (EWGSOP) has defined sarcopenia as low muscle mass with low muscle strength OR with low gait speed. With two cutoff points available for each of the three components of this definition, eight different methods of diagnosis of sarcopenia can be used.

Using the Eurostat online database, the researchers retrieved age and gender-specific population projections from 2016-2045 for 28 European countries. The age and gender-specific prevalence of sarcopenia was assessed from a study that precisely compared prevalence estimates according to the different diagnostic cutoffs of the EWGSOP proposed definition. The prevalence estimates were interpolated for adults above 65 years of age. The estimates of sarcopenia prevalence were then applied to population projections until 2045. The results showed that using the definition providing the lowest prevalence estimates, the number of individuals with sarcopenia in Europe in 2016 is 10,869,527. This will rise to 18,735,173 in 2045 (a 72.4% increase). The overall prevalence of sarcopenia in the elderly will rise from 11.1% in 2016 to 12.9% in 2045. Women currently account for 44.2% of prevalent cases. Using the definition providing the highest prevalence estimates, the number of individuals with sarcopenia in Europe is 19,740,527 in 2016, rising to 32,338,990 in 2045 (a 63.8% increase). The overall prevalence of sarcopenia in the elderly will rise from 20.2% in 2016 to 22.3% in 2045. Women currently account for 66.4% of prevalent cases.

"Regardless of which diagnostic cutoff is used to define sarcopenia, the prevalence of sarcopenia is expected to rise substantially in Europe. It is therefore essential that we implement effective prevention and disease management strategies. Health authorities must take action in order to limit the impact on increasingly strained healthcare systems and to help Europeans enjoy healthy, active ageing."

Link: http://www.iofbonehealth.org/news/sarcopenia-which-affects-20-european-seniors-may-increase-63-2045


Are there any ways to partly inhibit myostatin by using currently available drugs or supplements? Would this have any preventive effect?

Posted by: Claus Elser at April 26th, 2016 8:22 AM

@Claus Elser: Not that I know of. The only therapies that might have an effect are those under development or in trials.

Posted by: Reason at April 26th, 2016 2:30 PM

@Reason: Thank you. Then physical activity is the only available option right now to slow sarcopenia.

Posted by: Claus Elser at April 27th, 2016 6:20 AM

Interesting, thanks.

Posted by: Claus Elser at April 28th, 2016 3:19 AM

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